Neuromodulators such as botulinum toxin relax the muscles on areas of the face and neck, which causes wrinkles associated with facial expressions or facial pain to be less noticeable or essentially disappear. Areas most frequently treated are a) glabellar area of frown lines, located between the eyes; b) crow’s feet (lateral areas of the eyes); c) forehead wrinkles; d) radial lip lines (smokers lines); e) head and neck muscles.